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Rather than targeting vascular tissues, PT-141 acts centrally in the brain through activation of melanocortin receptors located in the medial preoptic area (mPOA) of the hypothalamus, a critical region for regulating sexual behavior

neurological involvement requires more frequent maintenance dosing

A scalp serum may help some patients, but it should not delay a proper workup if hair loss is sudden, patchy, severe, or getting worse

Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence

A reference card of the molecular and physical attributes for the peptides in this formulation

Acknowledgments We thank Lauren Hayashi for assistance with experiments and Chris Riso for fish husbandry support