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It is majorly found circulating in the blood as GLP-1(7-36) amide that is produced primarily from three tissues of the human body: enteroendocrine L cells in the distal small bowel, cells in the pancreas, and the central nervous system ( Surprisingly, it took approximately 20 years from the discovery of GLP-1 to the authorized approval of worldwide utilized GLP-1 RAs
The pathophysiology of neuropathic pain varies and includes ectopic activity in damaged nerves or in adjacent nerves, dorsal root ganglion (DRG) or central pathways, and peripheral and central sensitisation involving numerous molecular mechanisms
Studies comment that when the peptide was selected for further pharmacokinetic evaluation, it was found to be present in plasma beyond 72 h. [1] It may therefore exhibit improved pharmacokinetics compared to GHRH
Gordon, Barbara MBA, RDN, LD
Who Should Consult Before Booking Women who are pregnant or nursing