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And this drug class itself does not have that many negative consequences

4.2 Stimuli-responsive nanoplatforms for spatiotemporal drug release The TME of osteosarcoma exhibits distinct physicochemical features, including acidic pH, elevated glutathione levels, and hypoxia, that can be exploited for stimuli-responsive drug release (45, 59)

Absolute cytotoxic T-cells (CD8 + ) ( Figure 6C ) were also significantly affected by the interaction of group and time (p G*T = 0.006)

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