GLP-1 receptor agonists mimic gut hormones to curb appetite and slow digestion, a mechanism driving the success of therapies from Novo Nordisk (Ozempic for diabetes and Wegovy for Lillys oral GLP-1 drug orforglipron achieves 12.4% weight loss in phase 3 trial but trails injectable rivals tirzepatide and retatrutide Lilly recently reported topline results from the ATTAIN-1 phase-3 trial evaluating orforglipron, a once-daily oral glucagon-like-peptide-1 (GLP-1) receptor agonist for adults with obesity or overweight without diabetes
Boutraa, T., Akhkha, A., Al-Shoaibi, A
Sin embargo, eso no muestra todo el panorama
GLP-1 medications like Wegovy and Mounjaro are helpful tools for supporting weight management because they help to regulate appetite and food intake, leading to significant changes in body weight and overall health
For example, one case study reported worsened lactose intolerance and new gluten intolerance following semaglutide treatment for weight loss
Those results were in HIV patients with lipodystrophy