Most digestive side effects such as nausea and bloating are most pronounced during treatment initiation or dose increases and typically diminish within a few weeks as the body adapts
This setting may allow earlier insights into treatment effects, particularly via DNA-methylation based epigenetic clocks and other emerging aging biomarkers, which are recently being considered as outcome measures in double-blind, randomized geroscience trials 17 and global competitions testing gerotherapeutics 18
In TRIUMPH-1, treatment discontinuations due to adverse events occurred at 4.1%, 6.9%, and 11.3% on the 4 mg, 9 mg, and 12 mg arms respectively, compared with 4.9% on placebo [2]
Holland, D
Organelle-specific mechanisms in crosstalk between apoptosis and ferroptosis
Clinical trials and real-world data have not identified direct interference between GLP-1 medications and thyroid hormone absorption or thyroid medication efficacy