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But how

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This chronic state of severe oxidative stress damages cellular membranes through a destructive process known as lipid peroxidation, creating a highly toxic internal cellular environment

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Here are some of the main culprits behind low glutathione: Chronic Stress: Constant stress elevates cortisol levels aka the stress hormone. While cortisol helps manage stress, excessive amounts increase oxidative stress, leading to glutathione depletion as it works to protect cells from damage