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A 2025 scoping review by McGuire and colleagues (Curr Rev Musculoskelet Med) found no adequately powered randomised controlled trials for BPC-157 in musculoskeletal healing
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Therefore, they are nowadays recommended as first line therapy in patients with T2DM and atherosclerotic cardiovascular disease to reduce events, regardless of baseline or target HbA1c and concomitant glucose-lowering medication according to the 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes [31]
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Patients taking metformin along with tirzepatide may be at increased risk for vitamin B12 deficiency, which can cause fatigue
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