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By use of multiple agent therapy, even wherein each agent is independently a sub-therapeutic dose, the rate of responsiveness is increased, such that the patient is responsive about 50% to about 100% of the time
It showed no negative impact on carbohydrate metabolism
Calorie restriction in C57BL/6 J mice mimics therapeutic fasting in humans
The magnitude remains important
In some cases, patients on GLP1 therapy lose lean body mass along with fat
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