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You need bloodwork before starting and monitoring throughout treatment
Irwin MR
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The initiation of BBB disruption can be direct, for example, due to an infection, or can be triggered by the activation of neuroinflammatory pathways following brain damage
The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida
Their condition did not resemble critical illness neuropathy
