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Fatty acids like LA and ALA play an important role in the maintenance of skin barrier function

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Eur J Immunol

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These, for example, include prodrug strategies, as seen in the case of OTC, which was designed to have improved bioavailability and stability (it is thought of being converted to cysteine intracellularly, which is then used for GSH synthesis) or NAC amide that has improved lipophilicity and cell permeability