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Lipolysis Enhancement and Lipogenesis Inhibition In obese Zucker rats, daily oral administration of AOD9604 significantly increased lipolytic activity in adipose tissue compared to controls, establishing direct adipocyte-level lipolysis stimulation as a key mechanism of action in pre-clinical models
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Additionally, NNMT inhibition has been linked to alterations in the SAM/SAH ratio, which may influence broader epigenetic methylation patterns
(7) Studies have examined changes in oxygen consumption, substrate utilization, and thermogenesis following NNMT inhibition
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