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Constipation management requires proactive hydration (100+ ounces daily), gradual fiber increase, and light movement after meals

In some cases, these biological and medical factors contribute to obesity, a chronic disease that often requires long-term management

In addition, Japanese guidelines published in 2022, including Eculizumab, stated this should be considered when more established modalities of IVIG or plasma exchange are inadequate to control symptoms

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Retatrutides 24.2% is the largest figure ever recorded in a Phase 2 obesity trial