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Thomas et al., 2022)

This size-based penetration advantage is central to its topical research applications and helps explain why laboratory studies have consistently demonstrated biological activity following topical application models

It identified no adequate acute, repeat-dose, genotoxicity, reproductive-toxicity or carcinogenicity programme

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So all of these things are helping prevent tissue damage in the thyroid gland, which helps prevent the immune system from going haywire trying to deal with that damage