GLP-1 also prevents MG-induced apoptosis of INS-1 and MIN 6 cells in part through PKA and PI3 kinase pathway, and partially via improving mitochondrial function and suppressing prolonged AMPK activation In order to verify and confirm the anti-apoptotic effect and molecular mechanisms of GLP-1 on MG-induced beta cell apoptosis, we further repeated some experiments in both INS-1 and MIN6 cells
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We selected SURMOUNT-5 because its transparent, peer-reviewed, methodologically rigorous, and mirrors real-world GLP-1 use: weekly injections, common health challenges, modern obesity doses, identical background conditions
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