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When numerous macules are observed, they may be found in association with certain genetic conditions or syndromes When these macules occur in isolation, they are usually sporadic and no associated conditions are observed The skin condition is not infectious and does not spread from one individual to another

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Most tissues have a half-life (T 1/2 ) similar to plasma (3.7h) except for the liver and intestine with shorter T 1/2 and muscle, kidney, and red blood cells that have longer T 1/2

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