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Extended exposure (days to weeks) progressively reduces potency

An update on the potential role of excitotoxicity in the pathogenesis of Parkinsons disease

10.1021/acsami.1c24569 134 XuL.YanX.ZhaoY.WangJ.LiuB.YuS.et al (2022b)

Gene set enrichment analysis (GSEA) was performed with 1000 permutations to identify enriched biological functions and activated pathways from the molecular signatures database (MSigDB), which included hallmark gene sets, positional gene sets, curated gene sets, motif gene sets, computational gene sets, GO gene sets, oncogenic gene sets, and immunologic gene sets

Instead, many hormonal systems operate through rhythmic oscillations that influence receptor sensitivity, intracellular adaptation, and transcriptional responses

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