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The translocated cyt c hijacks histone chaperones such as suppressor of variegation, enhancer of zeste and trithorax (SET)/template-activating factor (TAF)-I, inhibiting the nucleosome assembly/disassembly activity and DNA repairing (Gonzlez-Arzola et al., 2015
14 Additionally, Hosp et al suggested that there is an association between altered cerebral metabolism in cognitive impairment as 10 out of 15 patients presented frontoparietal hypometabolism using fluorodeoxyglucose (FDG) positron emission tomography (PET) scan
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport
Gene and protein expression of key TCA enzymes is also reduced in these models, while milder impact models actually demonstrate a gradual increase in these enzymes as mice recover from impact [75]
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