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dose reduction of these medications may be needed) [1] Acute kidney injury risk, particularly with severe gastrointestinal adverse reactions causing dehydration Diabetic retinopathy complications , particularly in patients with a history of retinopathy who experience rapid improvement in blood glucose [1] Acute gallbladder disease including cholelithiasis and cholecystitis The FDA label includes a boxed warning about thyroid C-cell tumors observed in rodent studies, though the relevance to humans remains uncertain

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This discomfort may worsen with prolonged standing or walking and improve when sitting or leaning forward

The FDA review process typically takes 6 to 12 months for a standard review, or 6 months for priority review if granted