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[15] Mechanism of action [edit] Upon binding to its ligand GLP-1, the GLP-1 receptor activates intracellular signaling pathways that regulate insulin secretion, glucose metabolism, and satiety

In addition to peripheral effects, certain hepatokines, such as FGF-21, SELENOP, Fetuin-A, ANGPTL3, MANF, Adropin, ApoJ, and SHBG, exhibit direct or indirect effects on the CNS and represent promising therapeutic targets for AD (Figure.2)

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A head-to-head review of clinical studies determined that among available GLP-1 RAs, there were A1C reductions from 0.78% to 1.9%