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Neoadjuvant chemotherapy is associated with increased expression of DNA repair proteins and epithelial to mesenchymal transition (EMT) in patients with non-small cell lung cancer (NSCLC)

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Serious adverse effects are uncommon in healthy adults but can include elevated homocysteine levels if methionine metabolism is impaired, which is why patients with MTHFR gene variants should use methylated B-vitamin formulations instead of standard Lipo C