Kohler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, et al
12, oxidative stress and antioxidant capacity were evaluated by measuring GST, GSH, and myeloperoxidase (MPO)
Direct control of the rate-limiting enzyme in glutathione production provides a post-translational switch for responding to intracellular oxidative signals
[252] [253] The main metabolic pathways involve aromatic para-hydroxylation, aliphatic alpha- and beta-hydroxylation, N -oxidation, N -dealkylation, and deamination
Informacin adicional
For example, Metformin, an AMPK activator and complex I inhibitor, has been suggested to confer organ protection via multiple mechanisms: it reduces hyperglycemia (high sugars can worsen mitochondrial injury), activates AMPK which stimulates antioxidant defenses and mitophagy, and skew metabolism away from pure glycolysis