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5-Amino-1MQs confirmed high selectivity documented not to inhibit related SAM-dependent methyltransferases or NAD+ salvage pathway enzymes makes it the most validated small-molecule NNMT research tool currently available, and ensures that experimental findings can be reliably attributed to NNMT inhibition rather than off-target effects
Gastroenterology 137 (5), 1716-24.e12
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In preclinical research, AOD9604 is primarily investigated for its selective lipolytic activitythe ability to stimulate fat breakdown (lipolysis) and inhibit fat synthesis (lipogenesis) without exhibiting the growth-promoting or diabetogenic effects of full-length growth hormone
