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doi: 10.1016/j.bbi.2012.02.008 424 BalinasCEaton-FitchNMaksoudRStainesDMarshall-GradisnikS

Preventing this decrease, with the administration of a SIRT-1 activator, reversed ROS bursts, increased downstream nuclear PGC-1a and Nrf2 expression, and attenuated increases in mitochondrial membrane potential and neuronal apoptosis induced by ischemia/reperfusion injury [78]

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Clinical evidence : a 2018 study by Mattson et al., reviewed the effects of IF on brain health, citing human studies that showed improvements in cognitive function and reduced markers of neuroinflammation (Mattson et al., 2018)

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Optimal collagen organization develops