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Semaglutide (Wegovy, Ozempic) : Once-weekly injection Works on GLP-1 receptors 10-15% average body weight loss in clinical trials FDA-approved for chronic weight management Well-studied and proven effective Tirzepatide (Mounjaro, Zepbound) : Weekly injection Works on both GLP-1 and GIP receptors (dual action) Newer but showing strong results Can be effective for people who havent responded to semaglutide Risk is minimized when prescribed and monitored by a medical professional, such as a nurse practitioner or physician