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What affects SHBG: Estrogen increases SHBG (oral estrogen more than transdermal) Insulin resistance and obesity decrease SHBG Thyroid function affects SHBG (hyperthyroidism increases it) Body weight strongly correlates with SHBG (higher BMI = lower SHBG) [16] SHBG and metabolic health: The SWAN study found that increasing SHBG levels during the menopausal transition were associated with a 10% reduced risk of developing diabetes [17]

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How The Body Handles Excess B12 As mentioned above, vitamin B12 is a water-soluble vitamin

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