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Patients with a history of retinopathy should undergo ophthalmologic evaluation before initiating therapy and be monitored closely during treatment, as determined by the prescribing clinician
In several animal species, for example, the drug exenatide has been able to help reduce cocaine self-administration, decrease the frequency of relapse-like behavior, and reduce dopamine release after cocaine is consumed
We also observed a significant improvement in oral disposition index, a dynamic measure of pancreatic beta cell function that has been adjusted for the influence of prevailing insulin sensitivity level, in the high GLP-1 prediabetes group treated with linagliptin
The development of small molecule oral agonists could revolutionize the landscape of GLP-1 therapies, improving patient compliance and ultimately leading to better health outcomes
Utilization impact At the same time, if GLP-1s lead to sustained weight loss and better metabolic health, they could reduce the incidence of costly chronic conditions such as kidney disease or heart failure
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