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Monitoring Response Patients or research participants typically notice: Appetite suppression within the first 12 weeks Early satiety and slower gastric emptying by weeks 34 Weight loss trends becoming evident by week 8 Continued improvements in glucose metabolism when paired with semaglutide or tirzepatide Side Effects and Considerations Common side effects include: Nausea Mild gastrointestinal discomfort Constipation Injection site reactions These effects are generally transient and dose-dependent, which is why titration is important

International Journal of Molecular Sciences, 18 (12), 2573

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Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo

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Hu et al., 2022