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This article delineates the mechanistic interplay in PD between S pathology, sirtuin dysregulation, and impaired insulin signaling, illustrating how systemic metabolic dysfunction may contribute to the progression of neurodegeneration
doi: 10.3390/cells11233924 41 FuQXuLWangYJiangQLiuZZhangJet al
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At therapeutic doses used for diabetes or moderate weight management, the anti-inflammatory effects may predominate
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