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The molecule also binds platinum-based chemotherapy drugs with hepatocyte-like cells to form a complex that leads to apoptosis or cell death by necrosis

Transmission electron microscopy (TEM) confirmed that VRK2-KO cells treated with APR-017 exhibited increased shrunken mitochondria (Fig

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These are the early signs of vascular compromise and they require immediate intervention with high-dose hyaluronidase, warm compress, nitroglycerin paste, aspirin, and emergency escalation when applicable

Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA

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