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Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities
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Vitamin B12 is also involved in homocysteine metabolism and is critical in proper energy metabolism, immune function, and nerve function
When NNMT levels are high, its harder for people to lose weight
They make clinical sense when managing documented metabolic adaptation, addressing specific complaints of profound fatigue on GLP-1s, or when gastrointestinal side effects prevent the use of standard therapies
Oral vitamin B12 is generally safe to take at recommended doses
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