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These reports do not establish a direct causative link between semaglutide and MTC, but they have raised concerns regarding the thyroid safety of patients using this class of medications (Machens et al., 2009

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GLP-1 signaling also directly downregulates proinflammatory cytokines in mucosal immune cells (55), consistent with a targeted hierarchy of mechanisms that prioritizes epithelial defense and local immune modulation over systemic immunosuppression

Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation