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It is of critical importance that future studies directly evaluate sex-specific effects of these compounds to fully assess their clinical potential

Reference lists of key articles and major clinical practice guidelines were manually screened to identify any additional relevant studies

One paper suggested that GLP-1s may improve some gut health symptoms (such as abdominal pain) but worsen others (such as regularity and constipation)

Many patients struggle to stay on these medications long enough to see lasting benefits

Individual responses vary and clinical appropriateness is determined on a case-by-case basis

Gradual dose increases and ongoing monitoring help reduce discomfort while maintaining effectiveness