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Catching this early allows for intervention before problems become significant

An OA mouse model was successfully established by injecting monosodium iodoacetate (MIA) in mouse knee joints 25 , specifically, involving anesthetic administration with 1.25% tribromoethanol (Bimake, M2920) at a dose of 0.2 mL/10 g body weight, followed by intra-articular injection of 10 L MIA (50 mg/ml, Sigma-Aldrich, 57858-25G-F) into the right knee joint using a 30-gauge needle

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The ability of green tea to exert anti-UF activity is mainly attributed by epigallocatechin gallate (EGCG), one of the main active constituents in green tea, which constitutes more than 40% of the total polyphenol of green tea catechin and is present at about 142 mg in a 200 ml of green tea (Yang and Wang, 1993)

Heart rate effects during this window may not be representative of the eventual stable-state response

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo