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This dysfunction affects not only the endothelial cells of the coronary vessels but more crucially those in the intramyocardial capillaries and endocardium, where they interact directly with adjacent cardiomyocytes [12]

262 Notably, the NADPH-dependent redox system is considered a central regulator of ferroptosis

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Comparacin directa entre dos GLP-1 oral ACHIEVE-3 proporciona los primeros datos de comparacin directa entre dos frmacos GLP-1 oral en diabetes tipo 2, en los que orforglipron ha mostrado mayores reducciones de HbA1c y peso que semaglutida oral en las dosis aprobadas para diabetes, afirm el Julio Rosenstock, profesor clnico de Medicina en el Centro Mdico Southwestern de la Universidad de Texas e investigador principal de ACHIEVE-3