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When used alongside sulphonylureas (e.g., gliclazide) or insulin , there may be an increased risk of hypoglycaemia

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The drugs, which are currently in clinical trials but only for the treatment of noncirrhotic NASH, include the farnesoid X receptor agonist obeticholic acid (OCA), the thyroid hormone receptor THR agonist (Resmetirom), and Aramchol (bile acid and FA conjugate, cholic acidarachidic acid) (3032)

TakenouchiTSugiuraYMorikawaTNakanishiTNagahataYSugiokaTet al

In the CFA-induced chronic inflammatory pain model, mice with CFA-induced inflammation presented prolonged heat hyperalgesia following intraplantar vehicle administration

T2DM patients combined with MASLD appear to respond better to EX-BID or EX-QW compared to those without MASLD, resulting in greater benefits in terms of LFC and cardiometabolic improvement