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Proteostasis maintenance of protein homeostasis in cells, involving processes that regulate protein synthesis, folding, degradation, and clearance to ensure proper protein function and prevent cellular dysfunction and disease

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CKD and HF commonly coexist and exacerbate each other, as CKD increases the risk of HF, while HF accelerates kidney function decline [17]

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Moreover, several specifically designed randomized clinical trials demonstrated a significant reduction in the incidence of cardiovascular events (CV) with some of these agents [2,3,4]

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