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Table of Contents What Is Retatrutide and How Does It Work in the Body Common Side Effects and Sensations Reported With Retatrutide Managing Uncomfortable Symptoms During Treatment When to Seek Medical Advice About How You Are Feeling What Current Evidence and Clinical Trials Tell Us Scientific References Frequently Asked Questions What Is Retatrutide and How Does It Work in the Body Retatrutide is an investigational once-weekly subcutaneous injection that activates GLP-1, GIP, and glucagon receptors simultaneously, slowing gastric emptying, reducing appetite, enhancing insulin secretion, and potentially increasing energy expenditure

Eating smaller meals, avoiding overly rich foods, and remaining well-hydrated may help reduce symptoms

In contrast, tools like the structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders (DSM) can distinguish clinical diagnoses such as major depressive disorder or generalized anxiety disorder

2017 Aug;29(4):466-471

It means fewer injections, but growth hormone stays elevated for longer, which can bring more side effects like swelling or blood sugar shifts

Rachel Nania is an award-winning health editor and writer at AARP.org, who covers a range of topics including diseases and treatments.