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At the immunological level, Cu deficiency may generate a deficiency in CD4 T-cell responses to mitogens [353], immune hyporesponsiveness (immune tolerance) [354], and an increased humoral response [355], again supporting the presence of an immunodeficiency

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Ferroptosis is an iron-dependent form of regulated cell death, closely associated with disruptions in iron homeostasis, dysfunction of amino acid antioxidant systems, and lipid peroxidation (Jiang et al., 2021