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Free radicals, characterized by one or more unpaired electrons, exhibit high reactivity, and their generation in biological systems predominantly involves oxygen and nitrogen species, including hydrogen peroxide (HO), organic hydroperoxides, nitric oxide, superoxide, and hydroxyl radicals 45

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These results support a mechanism in which postsynaptic septal GLP-1R activation regulates 2-AG levels to alter presynaptic DA homeostasis and cocaine actions through AA

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Given its pivotal physiological role, researchers have developed GLP-1 receptor agonists (GLP-1 RAs) through structural modifications