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What we do not know Multi-year continuous use has not been studied in humans
Coudrov G, Gburek J, Kozyraki R, Madsen M, Trugnan G, Moestrup SK, Verroust PJ, Maurice M
For instance, the development of autoimmune diseases is stimulated by iodine (excess or deficiency), smoking, stress, and chemical contaminants (like polyaromatic hydrocarbons), medicine (like amiodarone and interferon-alpha (IFN), and bacterial and viral infections (like hepatitis C virus and Yersinia enterocolitica)
The faster damaged tissue can stabilize, the less mechanical disruption occurs during the vulnerable early healing phase
doi: 10.1007/s00415-020-10362-z 58 PavelekZAngelucciFSouekOKrejsekJSobekLKlmovBet al