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Rare but serious problems can happen, and some medicines might not work right with B12 shots

Not having enough B12 can cause tiredness, tingling, memory issues, or mood shifts

Follow-up testing: Keep checking B12 levels and adjust treatment as needed, every 3-6 months

You can get pernicious anemia if: You have an autoimmune disease that makes your immune system attack the cells in your stomach that produce intrinsic factor, a protein that helps your body absorb B12

Some patients may benefit from weekly treatments, while others may only need one every month

You may experience minor pain and a tugging sensation during the procedure