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Modifications in intestinal microbial structure compromise barrier integrity, facilitating bacterial product migration into the portal circulation

Research Applications Areas Studied in Preclinical Research Published models across multiple tissue systems Metabolic & Obesity Research Weight Biology Triple receptor activation: GLP-1R for satiety/insulin, GIPR for fat mobilization, GcgR for thermogenesis and hepatic lipid clearance

Specifically, it enhances the bodys release of insulin following a meal, leading to better blood sugar control

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While generalised pruritus is not specifically listed as a common adverse reaction in the Ozempic SmPC, hypersensitivity reactions are recognised class effects of GLP-1 receptor agonists