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The best-characterized use of GHK-Cu is topical application in cosmetic formulations, where concentrations typically range from roughly 0.05% to 2%

Further examination by the same research team compared the actions of GHK-Cu with those of a control compound and vitamin K

It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation

It's also a good idea to avoid mixing copper peptides with strong oxidizing acne treatments like benzoyl peroxide in the same step, as this can exacerbate skin irritation and compromise peptide stability

Huang Z, Pinto JT, Deng H, Richie Jr JP

PMID 23631642