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In the OASIS-4 trial, about 74% of participants on oral semaglutide 25 mg experienced any GI adverse event versus 42% on placebo

If retatrutide produces better weight loss but costs significantly more, NICE may restrict it to specific patient groups while Mounjaro remains the first-line option

he duration of the program may vary based on individual goals and progress

Isotretinoin and tetracyclines are contraindicated due to a higher risk of benign intracranial hypertension

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