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Anti-inflammatory effects of GLP-1 medicines independent of weight loss Several GLP-1 medicines, including semaglutide, liraglutide, and exenatide, reduce plasma levels of C-reactive protein (CRP), a surrogate of systemic inflammation, in people with obesity or T2D

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Access this article Similar content being viewed by others Abbreviations ACSR: Anti-folate cytotoxic skin reaction AGEP: Acute generalized exanthematous pustulosis ALDEN: Algorithm for assessment of drug causality in epidermal necrolysis Anti PD-L1: Anti programmed death-ligand 1 APACHE: Acute physiology and chronic health evaluation BSA: Body surface area BSLE: Bullous systemic lupus erythematosus CBZ: Carbamazepine CsA: Cyclosporine A DIHS: Drug-induced hypersensitivity syndrome DRESS: Drug reaction with eosinophilia and systemic symptoms EBA: Epidermolysis bullosa acquisita EM: Erythema multiforme FACS: Fluorescence-activated cell sorting FasL: Fas ligand GBFDE: Generalized bullous fixed drug eruption GSTM1: Glutathione S-transferase Mu 1 GvHD: Graft versus host disease HLA: Human leukocyte antigen ICNARC: Intensive Care National Audit & Research Center IVIG: Intravenous immunoglobulins LABD: Linear IgA bullous dermatosis LTT: Lymphocyte transformation test MIEN: Methotrexate-induced epidermal necrolysis MRR: Mortality risk ratio NK cells: Natural killer cells NSAIDs: Nonsteroidal anti-inflammatory drugs PCR: Polymerase chain reaction SCORTEN: Severity-of-illness score for toxic epidermal necrolysis SJS: Stevens-Johnson syndrome SMR: Standardized mortality rate SMX/TMP: Sulfamethoxazole/trimethoprim SSSS: Staphylococcal scalded skin syndrome TBSA: Total body surface area TEN: Toxic epidermal necrolysis TNF: Tumor necrosis factor TRAIL: TNF-related apoptosis-inducing ligand TWEAK: TNF-like weak inducer of apoptosis VBDS: Vanishing bile duct syndrome References Stevens A, Johnson F (1922) A new eruptive fever associated with stomatitis and ophtalmia

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2 Department of Pediatrics, Pediatric Intensive Care Unit, CHU Caen, Caen, France Abstract: Acute hyperammonemia may induce a neurologic impairment leading to an acute life-threatening condition