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Initial in vivo testing with GEP12 (5 and 10 mg/kg/day) resulted in robust reductions in food intake and body weight, albeit somewhat less than responses observed in rats treated with equivalent doses of GEP44 (Figs
This can be caused by environmental factors, a demanding lifestyle, or simply the natural process of getting older
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Some reports in literature and reviews list risks like possible skin-peeling disorders (rare)
Folate and vitamin B12 are important cofactors of this mechanism, acting in the one-carbon metabolism
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