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Bacaro et al

In simple terms, lidocaine works because it works by blocking sodium channels in nerves, blocking nerve signals from reaching your brain

Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

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But knowing what to look for can help you identify fakes before you inject them