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European journal of nutrition , 54 (2), 251263
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Huang H
The International Journal of Dermatology published a systematic review of the risk factors of patients with exogenous ochronosis due to hydroquinone as highlighted below
In a 2025 review, after 1,200 mg intravenously twice a week for six weeks, 37.5% of participants reported lighter skin compared with 18.7% in the placebo group, and the effect faded after about six months
If the reaction worsens over six weeks rather than improving, the problem is not the copper uglies
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