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Risk estimates for breast cancer in DMPA users Based on the published SEER-18 2011 incidence rate (age-adjusted to the 2000 US Standard Population) of breast cancer for US women, all races, age 20 to 49 years, a doubling of risk would increase the incidence of breast cancer in women who use Depo-Provera CI from about 72 to about 144 cases per 100,000 women

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Peripheral neuropathy development due to vitamin B6 (pyridoxine) overdose may be irreversible, as well as kidney disease or calcifications (like kidney stones) in vitamin D overdose

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