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However, after synthesizing and testing a set of PROTACs this strategy was not successful
Minoxidil provides hair growth effects exclusively, while GHK-Cu offers systemic anti-aging, skin rejuvenation, and tissue repair benefits alongside hair restoration
Still, that effect did not replicate at scale in the larger, longer Phase IIb study designed to confirm it which is the standard reason a compounds development gets discontinued rather than a sign the compound is unsafe
However, arginine level depletion in patients sustained for about a week and returned to baseline level, suggesting that resistance on ADI-PEG20 may arise upon prolonged drug treatment [140, 141]
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